FICD (FIC Domain Protein Adenylyl Transferase) Deficiency Protects Mice From Hypertrophy‐Induced Heart Failure and Promotes BiP (Binding Immunoglobulin Protein) ‐Mediated Activation of the Unfolded Protein Response and Endoplasmic Reticulum‐Selective Autophagy in Cardiomyocytes

Background Cardiomyocytes require the HSP70 (heat shock protein 70) chaperone BiP (binding immunoglobulin protein) to maintain proteostasis in the endoplasmic reticulum (ER) following cardiac stress. The adenylyl transferase FICD (FIC domain protein adenylyl transferase) is increasingly recognized t...

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Autors principals:	Shannon M. Lacy, Rebecca J. Taubitz, Nicholas D. Urban, Samantha N. Turowski, Eric N. Primack, Eric D. Smith, Adam S. Helms, Daniel E. Michele, Matthias C. Truttmann
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2025-08-01
Col·lecció:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Matèries:	BiP ER FICD hypertrophy proteostasis
Accés en línia:	https://www.ahajournals.org/doi/10.1161/JAHA.124.040192
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