Pre-clinical model of dysregulated FicD AMPylation causes diabetes by disrupting pancreatic endocrine homeostasis

The bi-functional enzyme FicD catalyzes AMPylation and deAMPylation of the endoplasmic reticulum chaperone BiP to modulate ER homeostasis and the unfolded protein response (UPR). Human hFicD with an arginine-to-serine mutation disrupts FicD deAMPylation activity resulting in severe neonatal diabetes...

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Váldodahkkit:	Amanda K. Casey, Nathan M. Stewart, Naqi Zaidi, Hillery F. Gray, Hazel A. Fields, Masahiro Sakurai, Carlos A. Pinzon-Arteaga, Bret M. Evers, Jun Wu, Kim Orth
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Elsevier 2025-05-01
Ráidu:	Molecular Metabolism
Fáttát:	AMPylation BiP FicD Insulin Islet biology Neonatal diabetes
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S2212877825000274
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