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Intratracheally Administered Peptide-Modified Lipid Admixture Containing Fasudil and/or DETA NONOate Ameliorates Various Pathologies of Pulmonary Arterial Hypertension

This study examined the therapeutic potential of a combination therapy using fasudil, a Rho-kinase inhibitor, and DETA NONOate (DN), a nitric oxide donor, delivered as a lipid admixture modified with a cyclic homing peptide known as CAR (CAR-lipid mixture) for the treatment of pulmonary arterial hyp...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Tanoy Sarkar, Sakib M. Moinuddin, Ayman Isbatan, Jiwang Chen, David Mann, Fakhrul Ahsan
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2023-11-01
Schriftenreihe:Pharmaceuticals
Schlagworte:
pulmonary hypertension
fasudil
DETA NONOate
CAR-Peptide
CAR-lipid admixture
lung specific delivery
Online-Zugang:https://www.mdpi.com/1424-8247/16/12/1656
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