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Host-directed treatments for tuberculous meningitis utilizing a multi-platform approach across mouse and human models

Abstract Tuberculous meningitis (TB meningitis) is a major cause of death and neurological deficit despite recommended antibiotic and corticosteroid treatments, primarily due to dysregulated neuroinflammation. Here, we investigate a diverse panel of 12 immunomodulatory drugs as host-directed treatme...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Carlos E. Ruiz-Gonzalez, Medha Singh, Yuderleys Masias-Leon, Xueyi Chen, Mona O. Sarhan, Yazmin B. Martinez-Martinez, Sruti Patel, Madelynn Shambles, Andres Villabona-Rueda, Kadia Lissit, David Tweedie, Michael T. Scerba, William R. Bishai, Dmitri Artemov, Jin-Chong Xu, Franco D’Alessio, Richard Hafner, Nigel H. Greig, Maura Manion, Irini Sereti, Sanjay K. Jain
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2026-07-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-026-75202-6
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