Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling

Abstract Background Bone morphogenetic protein 4 (BMP4) is a potent inhibitor of breast cancer metastasis. However, a tumor-promoting effect of BMP4 is reported in other tumor types, especially when SMAD4 is inactive. Methods To assess the requirement for SMAD4 in BMP4-mediated suppression of metast...

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Detalhes bibliográficos

Principais autores:	Lap Hing Chi, Andrew D. Redfern, Suraya Roslan, Ian P. Street, Allan D. Burrows, Robin L. Anderson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-04-01
coleção:	Cell Communication and Signaling
Assuntos:	Breast cancer Metastasis BMP4 SMAD4 MYO1F Patient outcomes
Acesso em linha:	https://doi.org/10.1186/s12964-024-01559-0
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