BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis
BMP7/BMP2 or BMP7/BMP4 heterodimers are more active than homodimers in vitro, but it is not known whether these heterodimers signal in vivo. To test this, we generated knock in mice carrying a mutation (Bmp7R-GFlag) that prevents proteolytic activation of the dimerized BMP7 precursor protein. This m...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications Ltd
2019-09-01
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| Serija: | eLife |
| Teme: | |
| Online pristup: | https://elifesciences.org/articles/48872 |
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