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Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus

The ubiquitin-proteasome system (UPS) controls the majority of protein degradation in cells and dysregulation of the UPS has been implicated in the pathophysiology of numerous neurodegenerative disorders, including Alzheimer’s disease. Further, strong evidence supports a critical role for the UPS in...

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Principais autores: Morgan B. Patrick, Natalie J. Preveza, Shannon E. Kincaid, Gueladouan Setenet, Jennifer R. Abraham, Adam Cummings, Shifa Banani, W. Keith Ray, Richard F. Helm, Sydney Trask, Timothy J. Jarome
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-09-01
Serier:Brain Research Bulletin
Fag:
Aging
Memory
Hippocampus
Ubiquitin
Proteasome
Retrosplenial Cortex
Online adgang:http://www.sciencedirect.com/science/article/pii/S0361923024001485
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