Protein Synthesis Inhibition Activity of Mesothelin Targeting Immunotoxin LMB-100 Decreases Concentrations of Oncogenic Signaling Molecules and Secreted Growth Factors
LMB-100 is a mesothelin-targeted recombinant immunotoxin (iTox) that carries a modified <i>Pseuodomonas</i> exotoxin A (PE) payload. PE kills cells by inhibiting synthesis of new proteins. We found that treatment of pancreatic cancer cells with LMB-100 for 24⁻48 h did not change total protein...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI AG
2018-10-01
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| Col·lecció: | Toxins |
| Matèries: | |
| Accés en línia: | https://www.mdpi.com/2072-6651/10/11/447 |
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