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The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67phox

The superoxide (O2.-)-generating NADPH oxidase of phagocytes consists of a membrane component, cytochrome b558 (a heterodimer of Nox2 and p22phox), and four cytosolic components, p47phox, p67phox, p40phox, and Rac. The catalytic component, responsible for O2.- generation, is Nox2. It is activated by...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Edna eBechor, Iris eDahan, Tanya eFradin, Yevgeny eBerdichevsky, Anat eZahavi, Meirav eRafalowski, Aya eFederman-Gross, Edgar ePick
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015-02-01
Schriftenreihe:Frontiers in Chemistry
Schlagworte:
NADPH Oxidase
superoxide
synthetic peptides
NOX2
disulfide bonds
protein disulfide isomerase
Online-Zugang:http://journal.frontiersin.org/Journal/10.3389/fchem.2015.00003/full
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