Formulation and characterization of dolutegravir sodium-loaded nanostructured lipid carrier in situ gel for targeted brain delivery via intranasal route

Effective delivery of antiretroviral drugs to the brain is a major hurdle in treating central nervous system (CNS) HIV infections. This study developed an intranasal in situ gel containing dolutegravir sodium-loaded nanostructured lipid carriers (DTGs-NLCs) for targeted nose-to-brain delivery. DTGs-...

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Detalhes bibliográficos

Principais autores:	Salam Shanta Taher, Khalid K. Al-Kinani
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-01-01
coleção:	OpenNano
Assuntos:	Antiretroviral therapy Nanostructured lipid carriers (NLCs) NeuroAIDS Nose-to-brain delivery Thermosensitive gel
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352952025000386
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