Orchestrated desaturation reprogramming from stearoyl‐CoA desaturase to fatty acid desaturase 2 in cancer epithelial‐mesenchymal transition and metastasis

Abstract Background Adaptative desaturation in fatty acid (FA) is an emerging hallmark of cancer metabolic plasticity. Desaturases such as stearoyl‐CoA desaturase (SCD) and fatty acid desaturase 2 (FADS2) have been implicated in multiple cancers, and their dominant and compensatory effects have rece...

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Hauptverfasser:	Zhicong Chen, Yanqing Gong, Fukai Chen, Hyeon Jeong Lee, Jinqin Qian, Jing Zhao, Wenpeng Zhang, Yamin Li, Yihui Zhou, Qiaobing Xu, Yu Xia, Liqun Zhou, Ji‐Xin Cheng
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2025-03-01
Schriftenreihe:	Cancer Communications
Schlagworte:	metabolic reprogramming stearoyl‐CoA desaturase fatty acid desaturase 2 epithelial‐mesenchymal transition cancer metastasis
Online-Zugang:	https://doi.org/10.1002/cac2.12644
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