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Orchestrated desaturation reprogramming from stearoyl‐CoA desaturase to fatty acid desaturase 2 in cancer epithelial‐mesenchymal transition and metastasis

Abstract Background Adaptative desaturation in fatty acid (FA) is an emerging hallmark of cancer metabolic plasticity. Desaturases such as stearoyl‐CoA desaturase (SCD) and fatty acid desaturase 2 (FADS2) have been implicated in multiple cancers, and their dominant and compensatory effects have rece...

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Principais autores: Zhicong Chen, Yanqing Gong, Fukai Chen, Hyeon Jeong Lee, Jinqin Qian, Jing Zhao, Wenpeng Zhang, Yamin Li, Yihui Zhou, Qiaobing Xu, Yu Xia, Liqun Zhou, Ji‐Xin Cheng
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-03-01
Serier:Cancer Communications
Fag:
metabolic reprogramming
stearoyl‐CoA desaturase
fatty acid desaturase 2
epithelial‐mesenchymal transition
cancer metastasis
Online adgang:https://doi.org/10.1002/cac2.12644
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