Recurrent evolution of ligand-binding domain multiplicity fine-tunes TGFβ signaling in vertebrates

Abstract From sponges to mammals, TGFβ signalling is a central regulator of body plan, cell fate and tissue homeostasis, with receptor architecture highly conserved across metazoans. Here we identify unexpected evolutionary divergence within a key receptor structure: 12 independent ligand-binding do...

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Bibliografiske detaljer

Principais autores:	Jerome Jatzlau, Michael Trumpp, Julia Kühlwein, Leon Obendorf, Yao Le, Heiner Kuhl, Marco Preussner, Paul-Lennard Mendez, Hendrik Burkert, Wiktor Burdzinski, Stefan Mundlos, Christoph Winkler, Matthias Stöck, Petra Knaus
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-05-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-026-73340-5
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