Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

Engineered neutralizing antibodies are potential therapeutics for numerous viruses, such as respiratory syncytial virus (RSV). Here, the authors develop an mRNA-based approach to express membrane-anchored neutralizing antibodies in the lung and demonstrate that it inhibits RSV infections in mice.

Bibliografiske detaljer

Principais autores:	Pooja Munnilal Tiwari, Daryll Vanover, Kevin E. Lindsay, Swapnil Subhash Bawage, Jonathan L. Kirschman, Sushma Bhosle, Aaron W. Lifland, Chiara Zurla, Philip J. Santangelo
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2018-10-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-018-06508-3
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