Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing

In this patient of invasive sinusitis due to Rhizopus arrhizus, Therapeutic drug monitoring (TDM) showed a high trough level (88mg/L) of isavuconazole on standard doses. Genotyping revealed CYP3A5∗3/∗3 polymorphism which indicated poor metabolism of isavuconazole. Switching to posaconazole was attem...

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Autors principals:	Rajeev Soman, Sanraksha Mayya, Rahul Doshi, Inderdeep Singh, Sushrut Ganpule
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-12-01
Col·lecció:	Medical Mycology Case Reports
Matèries:	Keyword_1 mucormycosis Keyword_2 isavuconazole Keyword_3therapeutic drug monitoring Keyword_4 CYP3A5 polymorphism
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211753925000454
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