Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing

In this patient of invasive sinusitis due to Rhizopus arrhizus, Therapeutic drug monitoring (TDM) showed a high trough level (88mg/L) of isavuconazole on standard doses. Genotyping revealed CYP3A5∗3/∗3 polymorphism which indicated poor metabolism of isavuconazole. Switching to posaconazole was attem...

Descrición completa

Detalles Bibliográficos

Principais autores:	Rajeev Soman, Sanraksha Mayya, Rahul Doshi, Inderdeep Singh, Sushrut Ganpule
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-12-01
Series:	Medical Mycology Case Reports
Assuntos:	Keyword_1 mucormycosis Keyword_2 isavuconazole Keyword_3therapeutic drug monitoring Keyword_4 CYP3A5 polymorphism
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211753925000454
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!