Mitochondrial calcium uniporter promotes MSU crystal-induced inflammation through inducing mitochondrial Ca2+ overload and ubiquitination of SIRT5 protein

Abstract Background The mitochondrial calcium uniporter (MCU) is the key channel regulating mitochondrial calcium (Ca²⁺) uptake. Growing evidence indicates that mitochondrial Ca²⁺ homeostasis plays a pivotal role in regulating immune cell function. However, how MCU contributes to MSU crystal-driven...

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Detalhes bibliográficos

Principais autores:	Qingqing Yu, Renjie Li, Guizhao Yang, Yan Xiao, Xingyu Liu, Yaxin Deng, Xiongyan Luo, Qian Dai, Mei Zeng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-08-01
coleção:	Arthritis Research & Therapy
Assuntos:	MCU MSU crystals Mitochondrial Ca2+ TRIM21 SIRT5
Acesso em linha:	https://doi.org/10.1186/s13075-025-03627-3
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