Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux

BackgroundInhibition of sphingosine kinase 1 (SphK1), which catalyzes bioactive lipid sphingosine-1–phosphate (S1P), attenuates NLRP3 inflammasome activation. S1P exerts most of its function by binding to S1P receptors (S1PR1-5). The roles of S1P receptors in NLRP3 inflammasome activation remain unc...

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Hlavní autoři:	Yingqin Wang, Chen Wang, Qiaolan He, Guannan Chen, Jie Yu, Jing Cang, Ming Zhong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-01-01
Edice:	Frontiers in Immunology
Témata:	sepsis NLRP3 inflammasome sphingosine-1-phosphate receptor TWIK2 macrophage
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1090202/full
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