ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation

The NLRP3 inflammasome is a multiprotein complex responsible for the maturation of precursor forms of interleukin (IL)-1β and IL-18 into active proinflammatory cytokines. Increasing evidence suggests that modulation of redox homeostasis contributes to the activation of the NLRP3 inflammasome. Howeve...

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Autori principali:	Tianli Zhang, Hiroyasu Tsutsuki, Waliul Islam, Katsuhiko Ono, Kohsuke Takeda, Takaaki Akaike, Tomohiro Sawa
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2021-05-01
Serie:	Redox Biology
Soggetti:	NLRP3 inflammasome Glutathione ATP GSH efflux Reactive oxygen species Redox regulation
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2213231721000781
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