Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1
A comparison between avian and human influenza A virus polymerases suggests that mutations in the PA subunit from 2009 pH1N1 enhanced cytosolic accumulation and translation of viral mRNA, in a manner dependent on the RNA binding protein, GRSF1.
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2022-10-01
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| Serie: | Communications Biology |
| Accesso online: | https://doi.org/10.1038/s42003-022-04082-5 |
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