The mammalian Ire1 inhibitor, 4µ8C, exhibits broad anti-Aspergillus activity in vitro and in a treatment model of fungal keratitis
ObjectiveThe fungal unfolded protein response consists of a two-component relay in which the ER-bound sensor, IreA, splices and activates the mRNA of the transcription factor, HacA. Previously, we demonstrated that hacA is essential for Aspergillus fumigatus virulence in a murine model of fungal ker...
Salvato in:
| Autori principali: | , , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2024-11-01
|
| Serie: | Frontiers in Cellular and Infection Microbiology |
| Soggetti: | |
| Accesso online: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1477463/full |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|