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<i>Aspergillus fumigatus</i> Fumagillin Contributes to Host Cell Damage

The activity of fumagillin, a mycotoxin produced by <i>Aspergillus fumigatus</i>, has not been studied in depth. In this study, we used a commercial fumagillin on cultures of two cell types (A549 pneumocytes and RAW 264.7 macrophages). This toxin joins its target, MetAP2 protein, inside cells and, a...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xabier Guruceaga, Uxue Perez-Cuesta, Aize Pellon, Saioa Cendon-Sanchez, Eduardo Pelegri-Martinez, Oskar Gonzalez, Fernando Luis Hernando, Emilio Mayayo, Juan Anguita, Rosa M. Alonso, Nancy P. Keller, Andoni Ramirez-Garcia, Aitor Rementeria
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-11-01
Schriftenreihe:Journal of Fungi
Schlagworte:
fumagillin
<i>Aspergillus fumigatus</i>
virulence factor
pathogenesis
RAW 264.7
A549
Online-Zugang:https://www.mdpi.com/2309-608X/7/11/936
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