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Exploring Structure–Activity Relationships of Niclosamide-Based Colistin Potentiators in Colistin-Resistant Gram-Negative Bacteria

Colistin is primarily used as a last resort antibiotic against highly resistant Gram-negative bacteria (GNB). Rising rates of colistin resistance, however, may limit future use of this agent. The anthelmintic drug niclosamide has been shown to enhance colistin activity in combination therapy, but a...

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Principais autores: Liam Berry, Quinn Neale, Rajat Arora, Danyel Ramirez, Marc Brizuela, Ronald Domalaon, Gilbert Arthur, Frank Schweizer
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-01-01
coleção:Antibiotics
Assuntos:
colistin
niclosamide
antibiotic
adjuvant
Gram-negative bacteria
Acesso em linha:https://www.mdpi.com/2079-6382/13/1/43
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