A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

ABSTRACT Doxorubicin (Dox) is a widely employed chemotherapeutic agent, but its use is clinically limited by dose‐accumulative cardiotoxicity. More specifically, Dox induces oxidative stress and causes pro‐apoptotic ceramide accumulation in cardiomyocytes (CMs). Acid ceramidase (AC) modified mRNA (m...

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主要な著者:	Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi
フォーマット:	Artigo
言語:	Inglês
出版事項:	Wiley 2026-02-01
シリーズ:	Advanced Science
主題:	cardiac‐selective delivery modified mRNA Dox cardiotoxicity
オンライン･アクセス:	https://doi.org/10.1002/advs.202510543
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