A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

ABSTRACT Doxorubicin (Dox) is a widely employed chemotherapeutic agent, but its use is clinically limited by dose‐accumulative cardiotoxicity. More specifically, Dox induces oxidative stress and causes pro‐apoptotic ceramide accumulation in cardiomyocytes (CMs). Acid ceramidase (AC) modified mRNA (m...

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Auteurs principaux:	Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2026-02-01
Collection:	Advanced Science
Sujets:	cardiac‐selective delivery modified mRNA Dox cardiotoxicity
Accès en ligne:	https://doi.org/10.1002/advs.202510543
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