Inactivation of the Thymidylate Synthase thyA in Non-typeable Haemophilus influenzae Modulates Antibiotic Resistance and Has a Strong Impact on Its Interplay with the Host Airways

Antibacterial treatment with cotrimoxazol (TxS), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate synthase gene thyA, which can modify the biology of infection. The opportunisti...

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Autori principali:	Irene Rodríguez-Arce, Sara Martí, Begoña Euba, Ariadna Fernández-Calvet, Javier Moleres, Nahikari López-López, Montserrat Barberán, José Ramos-Vivas, Fe Tubau, Carmen Losa, Carmen Ardanuy, José Leiva, José E. Yuste, Junkal Garmendia
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2017-06-01
Serie:	Frontiers in Cellular and Infection Microbiology
Soggetti:	Haemophilus influenzae thymidylate synthase thymidine auxotrophy thymidine uptake bacterial morphology antibiotic resistance
Accesso online:	http://journal.frontiersin.org/article/10.3389/fcimb.2017.00266/full
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