Inactivation of the Thymidylate Synthase thyA in Non-typeable Haemophilus influenzae Modulates Antibiotic Resistance and Has a Strong Impact on Its Interplay with the Host Airways

Antibacterial treatment with cotrimoxazol (TxS), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate synthase gene thyA, which can modify the biology of infection. The opportunisti...

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主要な著者:	Irene Rodríguez-Arce, Sara Martí, Begoña Euba, Ariadna Fernández-Calvet, Javier Moleres, Nahikari López-López, Montserrat Barberán, José Ramos-Vivas, Fe Tubau, Carmen Losa, Carmen Ardanuy, José Leiva, José E. Yuste, Junkal Garmendia
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2017-06-01
シリーズ:	Frontiers in Cellular and Infection Microbiology
主題:	Haemophilus influenzae thymidylate synthase thymidine auxotrophy thymidine uptake bacterial morphology antibiotic resistance
オンライン･アクセス:	http://journal.frontiersin.org/article/10.3389/fcimb.2017.00266/full
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