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Large-Scale Expansion of Human Liver Stem Cells Using Two Different Bioreactor Systems

The assessment of human liver stem cells (HLSCs) as cell therapeutics requires scalable, controlled expansion processes. We first focused on defining appropriate process parameters for HLSC expansion such as seeding density, use of antibiotics, optimal cell age and critical metabolite concentrations...

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Furkejuvvon:
Váldodahkkit: Jan Thorbow, Andrea Strauch, Viktoria Pfening, Jan-Philip Klee, Patricia Brücher, Björn Boshof, Florian Petry, Peter Czermak, Maria Beatriz Herrera Sanchez, Denise Salzig
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: MDPI AG 2024-07-01
Ráidu:Bioengineering
Fáttát:
stirred-tank bioreactor
multi-plate bioreactor
scale-up
oxygen limitation
<i>k<sub>L</sub>a</i>
long-term cultivation
Liŋkkat:https://www.mdpi.com/2306-5354/11/7/692
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