Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice

The adenosine triphosphate–binding cassette transporter A7 (ABCA7) gene is ranked as one of the top susceptibility loci for Alzheimer's disease (AD). While ABCA7 mediates lipid transport across cellular membranes, ABCA7 loss of function has been shown to exacerbate amyloid-β (Aβ) pathology and compr...

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Hlavní autoři:	Xiaoye Ma, Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi, Can Zhang, Dan Lei, Yingxue Ren, Keiji Kawatani, Skylar C. Starling, Ralph B. Perkerson, Bhaskar Roy, Astrid C. Quintero, Tammee M. Parsons, Yining Pan, Zonghua Li, Minghui Wang, Hanmei Bao, Xianlin Han, Guojun Bu, Rudolph E. Tanzi, Takahisa Kanekiyo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-03-01
Edice:	Neurobiology of Disease
Témata:	ABCA7 Alzheimer's disease Amyloid-β Lipids Microglia
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0969996125000294
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