CD2AP at the junction of nephropathy and Alzheimer’s disease

Abstract Polymorphisms in the gene encoding CD2-associated protein (CD2AP) are associated with an increased risk for developing Alzheimer’s disease (AD). Intriguingly, variants in the gene also cause a pattern of kidney injury termed focal segmental glomerulosclerosis. Recent studies have investigat...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Milene Vandal, Mohsen Janmaleki, Isabel Rea, Colin Gunn, Sotaro Hirai, Jeff Biernaskie, Justin Chun, Grant Gordon, Andrey Shaw, Amir Sanati-Nezhad, Gerald Pfeffer, Frederic Calon, Minh Dang Nguyen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-06-01
Schriftenreihe:	Molecular Neurodegeneration
Schlagworte:	CD2AP Alzheimer Kidney-brain axis Brain-body interactions Neurodegeneration Sexual dimorphism
Online-Zugang:	https://doi.org/10.1186/s13024-025-00852-x
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