Dual-target ligand discovery for Alzheimer’s disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation

Alzheimer disease (AD) is one of the major neurodegenerative diseases that could not be prevented or completely cured and may lead to death. Here, we target AChE and β-amyloid proteins. Synthesising new triphenylphosphporanylidene derivatives based on the surveyed literature and testing their biolog...

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Principais autores:	Marwa El-Hussieny, Mansoura A. Abd-El-Maksoud, Fouad M. Soliman, Marwa A. Fouad, Mohamed K. El-Ashrey
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2023-12-01
coleção:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	Triphenylphosphoranylidene silane acetylcholinesterase β-amyloid Alzheimer’s disease
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2166040
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