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Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents

IntroductionThe multi-targeted ligands (MTDL) strategy has been recognized as a promising Approach for the development of effective treatments against Alzheimer’s disease (AD), due to the presence of multiple pathological mechanisms in AD. In this study, a series of bis(7)-harmine derivatives were d...

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Principais autores: Hongtao Du, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-01-01
Serier:Frontiers in Chemistry
Fag:
Alzheimer’s disease
harmine
acetylcholinesterase
monoamine oxidase
amyloid peptide (Aβ)
Online adgang:https://www.frontiersin.org/articles/10.3389/fchem.2025.1545908/full
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