Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease

<p>Abstract</p> <p>Background</p> <p>The non-pathogenic course of SIV infection in its natural host is characterized by robust viral replication in the absence of chronic immune activation and T cell proliferation. In contrast, acutely lethal enteropathic SIVsmm strain PBj induces a strong immune ac...

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Главные авторы:	Prüfer Steffen, Panitz Sylvia, Coulibaly Cheick, Plesker Roland, Kirchhoff Frank, Schindler Michael, Münch Jan, Berger André, Mühlebach Michael D, Sanzenbacher Ralf, Tschulena Ulrich, Muckenfuss Heide, Hamdorf Matthias, Schweizer Matthias, Cichutek Klaus, Flory Egbert
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2011-03-01
Серии:	Retrovirology
Online-ссылка:	http://www.retrovirology.com/content/8/1/14
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