Simian-Human Immunodeficiency Virus (SHIV) Containing the nef/Long Terminal Repeat Region of the Highly Virulent SIV(smm)PBj14 Causes PBj-Like Activation of Cultured Resting Peripheral Blood Mononuclear Cells, but the Chimera Showed No Increase in Virulence

SIV(smm)PBj14 is a highly pathogenic lentivirus which causes acute diarrhea, rash, massive lymphocyte proliferation predominantly in the gastrointestinal tract, and death within 7 to 14 days. In cell culture, the virus has mitogenic effects on resting macaque T lymphocytes. In contrast, SIV(mac)239...

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Detalhes bibliográficos
Main Authors: Stephens, Edward B., Mukherjee, Sampa, Liu, Zhen Qian, Sheffer, Darlene, Lamb-Wharton, Rebecca, Leung, Kevin, Zhuge, Wu, Joag, Sanjay V., Li, Zhuang, Foresman, Larry, Adany, Istvan, Narayan, Opendra
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Viral Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110099/
https://ncbi.nlm.nih.gov/pubmed/9573293
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