ALS’ Perfect Storm: <i>C9orf72</i>-Associated Toxic Dipeptide Repeats as Potential Multipotent Disruptors of Protein Homeostasis
Protein homeostasis is essential for neuron longevity, requiring a balanced regulation between protein synthesis and degradation. The clearance of misfolded and aggregated proteins, mediated by autophagy and the ubiquitin–proteasome systems, maintains protein homeostasis in neurons, which are post-m...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2024-01-01
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| coleção: | Cells |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/2073-4409/13/2/178 |
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