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Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila

Abstract A large intronic hexanucleotide repeat expansion (GGGGCC) within the C9orf72 (C9orf72-SMCR8 Complex Subunit) locus is the most prevalent genetic cause of both Frontotemporal Dementia (FTD) and Motor Neuron Disease (MND). In patients this expansion is typically hundreds to thousands of repea...

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Autori principali: Ryan J. H. West, Joanne L. Sharpe, André Voelzmann, Anna L. Munro, Ines Hahn, Richard A. Baines, Stuart Pickering-Brown
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2020-09-01
Serie:Acta Neuropathologica Communications
Soggetti:
Drosophila
Frontotemporal dementia
FTD
MND
Dipeptide-repeats
C9orf72
Accesso online:http://link.springer.com/article/10.1186/s40478-020-01028-y
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