Mechanisms of Immune Activation by c9orf72-Expansions in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with overlapping pathomechanisms, neurobehavioral features, and genetic etiologies. Individuals diagnosed with either disorder exhibit symptoms within a clinical spectrum. Symptoms of ALS involve ne...

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Hlavní autoři:	Kyle J. Trageser, Chad Smith, Francis J. Herman, Kenjiro Ono, Giulio Maria Pasinetti
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2019-12-01
Edice:	Frontiers in Neuroscience
Témata:	amyotrophic lateral sclerosis (ALS) frontotemporal dementia (FTD) C9orf72 innate immunity TDP-43 reactive oxygen species (ROS)
On-line přístup:	https://www.frontiersin.org/article/10.3389/fnins.2019.01298/full
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