Caveats of Using Overexpression Approaches to Screen Cellular Host IFITM Proteins for Antiviral Activity

Ectopic protein overexpression in immortalised cell lines is a commonly used method to screen host factors for their antiviral activity against different viruses. However, the question remains as to what extent such artificial protein overexpression recapitulates endogenous protein function. Previou...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Tina Meischel, Svenja Fritzlar, Fernando Villalón-Letelier, Jeffrey M. Smith, Andrew G. Brooks, Patrick C. Reading, Sarah L. Londrigan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-03-01
Colecção:	Pathogens
Assuntos:	respiratory viruses innate immunity IFITM proteins host antiviral factors influenza A virus parainfluenza virus
Acesso em linha:	https://www.mdpi.com/2076-0817/12/4/519
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!