Benchmarking computational methods for single-cell chromatin data analysis

Abstract Background Single-cell chromatin accessibility assays, such as scATAC-seq, are increasingly employed in individual and joint multi-omic profiling of single cells. As the accumulation of scATAC-seq and multi-omics datasets continue, challenges in analyzing such sparse, noisy, and high-dimens...

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Autors principals:	Siyuan Luo, Pierre-Luc Germain, Mark D. Robinson, Ferdinand von Meyenn
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2024-08-01
Col·lecció:	Genome Biology
Matèries:	Benchmark ScATAC-seq Clustering Feature engineering Dimensional reduction
Accés en línia:	https://doi.org/10.1186/s13059-024-03356-x
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