The presence of circulating human apolipoprotein J reduces the occurrence of cerebral microbleeds in a transgenic mouse model with cerebral amyloid angiopathy

Abstract Background Cerebral amyloid angiopathy (CAA) is characterized by amyloid-β (Aβ) deposition in cerebral vessels, leading to lobar cerebral microbleeds (CMB) and intracerebral hemorrhages (ICH). Apolipoprotein J (ApoJ) is a multifunctional chaperone related to Aβ aggregation and clearance. Ou...

Descrición completa

Detalles Bibliográficos

Principais autores:	Anna Bonaterra-Pastra, Montse Solé, Silvia Lope-Piedrafita, Maria Lucas-Parra, Laura Castellote, Paula Marazuela, Olalla Pancorbo, David Rodríguez-Luna, Mar Hernández-Guillamon
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-07-01
Series:	Alzheimer’s Research & Therapy
Assuntos:	Amyloid-β Apolipoprotein J Cerebral amyloid Angiopathy Cerebral microbleeds MMP-12
Acceso en liña:	https://doi.org/10.1186/s13195-024-01541-5
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!