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The presence of circulating human apolipoprotein J reduces the occurrence of cerebral microbleeds in a transgenic mouse model with cerebral amyloid angiopathy

Abstract Background Cerebral amyloid angiopathy (CAA) is characterized by amyloid-β (Aβ) deposition in cerebral vessels, leading to lobar cerebral microbleeds (CMB) and intracerebral hemorrhages (ICH). Apolipoprotein J (ApoJ) is a multifunctional chaperone related to Aβ aggregation and clearance. Ou...

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Principais autores: Anna Bonaterra-Pastra, Montse Solé, Silvia Lope-Piedrafita, Maria Lucas-Parra, Laura Castellote, Paula Marazuela, Olalla Pancorbo, David Rodríguez-Luna, Mar Hernández-Guillamon
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-07-01
Serier:Alzheimer’s Research & Therapy
Fag:
Amyloid-β
Apolipoprotein J
Cerebral amyloid Angiopathy
Cerebral microbleeds
MMP-12
Online adgang:https://doi.org/10.1186/s13195-024-01541-5
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