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Role of epigenetics and the transcription factor Sp1 in the expression of the D prostanoid receptor 1 in human cartilage

D prostanoid receptor 1 (DP1), a prostaglandin D2 receptor, plays a central role in the modulation of inflammation and cartilage metabolism. We have previously shown that activation of DP1 signaling downregulated catabolic responses in cultured chondrocytes and was protective in mouse osteoarthritis...

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Principais autores: Mehdi Najar, Sami G. Alsabri, Gadid G. Guedi, Makram Merimi, Frédéric Lavoie, Detlev Grabs, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Mohamed Benderdour, Hassan Fahmi
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Cell and Developmental Biology
Assuntos:
DP1
prostaglandin D2
chondrocyte
Sp1
epigenetics
DNA methylation
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fcell.2023.1256998/full
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