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A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium

Abstract Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repressive complex 1 (PRC1), whose recruitment is H3K27me3-dependent. Yet it is unclear how H3K27...

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Autori principali: Thomas Balan, Ambre Petitalot, Julien Richard Albert, Louise Abbou, Guillaume Chevreux, Bassem Al-Sady, Bihter Özdemir Aygenli, Till Bartke, Raphaël Margueron, Sandra Duharcourt
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2026-03-01
Serie:Genome Biology
Soggetti:
Polycomb repressive complex
Transposable elements
Histone modifications
Chromodomain
Nascent transcription
Programmed DNA elimination
Accesso online:https://doi.org/10.1186/s13059-026-04045-7
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