A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium

Abstract Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repressive complex 1 (PRC1), whose recruitment is H3K27me3-dependent. Yet it is unclear how H3K27...

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Autors principals:	Thomas Balan, Ambre Petitalot, Julien Richard Albert, Louise Abbou, Guillaume Chevreux, Bassem Al-Sady, Bihter Özdemir Aygenli, Till Bartke, Raphaël Margueron, Sandra Duharcourt
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-03-01
Col·lecció:	Genome Biology
Matèries:	Polycomb repressive complex Transposable elements Histone modifications Chromodomain Nascent transcription Programmed DNA elimination
Accés en línia:	https://doi.org/10.1186/s13059-026-04045-7
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