The Role of the Rare Variants in the Genes Encoding the Alpha-Ketoglutarate Dehydrogenase in Alzheimer’s Disease
There is increasing evidence that several mitochondrial abnormalities are present in the brains of patients with Alzheimer’s disease (AD). Decreased alpha-ketoglutarate dehydrogenase complex (αKGDHc) activity was identified in some patients with AD. The αKGDHc is a key enzyme in the Krebs cycle. Thi...
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| Format: | Artigo |
| Sprache: | Inglês |
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MDPI AG
2021-04-01
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| Schriftenreihe: | Life |
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| Online-Zugang: | https://www.mdpi.com/2075-1729/11/4/321 |
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