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The Role of the Rare Variants in the Genes Encoding the Alpha-Ketoglutarate Dehydrogenase in Alzheimer’s Disease

There is increasing evidence that several mitochondrial abnormalities are present in the brains of patients with Alzheimer’s disease (AD). Decreased alpha-ketoglutarate dehydrogenase complex (αKGDHc) activity was identified in some patients with AD. The αKGDHc is a key enzyme in the Krebs cycle. Thi...

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Principais autores: Dora Csaban, Klara Pentelenyi, Renata Toth-Bencsik, Anett Illes, Zoltan Grosz, Andras Gezsi, Maria Judit Molnar
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-04-01
Serier:Life
Fag:
alpha-ketoglutarate dehydrogenase complex
αKGDHc
Alzheimer
dementia
DLD
rare variants
Online adgang:https://www.mdpi.com/2075-1729/11/4/321
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