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ALK Deletion Exons 2 to 19: Case Report of a Rare ALK Inhibitor–Responsive Lung Cancer Driver Oncogene

ALK internal deletions of nonkinase domain exons occur in 0.01% of lung cancers with ALK genomic aberrations. We report a lung adenocarcinoma with a previously undescribed somatic ALK deletion of exons 2 to 19 with dramatic and sustained (>23 mo) response to alectinib. Our and other reported cases w...

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Main Authors: Zachary R. Schoepflin, MD, Emmeline Academia, PharmD, Soravis A. Osataphan, MD, Deepa Rangachari, MD, Sheida Sharifi, MD, PhD, Paul A. VanderLaan, MD, PhD, Daniel B. Costa, MD, PhD
Format: Artigo
Language:Inglês
Published: Elsevier 2023-04-01
Series:JTO Clinical and Research Reports
Subjects:
Lung cancer
ALK
Deletion
Alectinib
Case report
Online Access:http://www.sciencedirect.com/science/article/pii/S2666364323000280
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