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Rapid and potent induction of protective mucosal immunity against SARS-CoV-2 by an adenovirus-vectored nanoparticle vaccine

Abstract Effective vaccine design ideally elicits potent, durable, and broad-spectrum immunity against rapidly evolving pathogens. However, current platforms, such as recombinant adenovirus vectors and protein nanoparticles, are developed and administered separately, and each has distinct immunologi...

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Principais autores: Shixiong Li, Qiong Zi, Junhao Fan, Guangzhen Jiang, Yao Zhang, Danni Feng, Zumrat Nur, Xiaoqing Liu, Jintao Lai, Tao Chen, Xiancai Ma, ZhangYong Hong, Jingyou Yu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Journal of Nanobiotechnology
Fag:
Adenoviral vectors
Nanoparticle
Antibody response
T cell response
GC reaction
Self-assembly.
Online adgang:https://doi.org/10.1186/s12951-026-04326-0
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