Rapid and potent induction of protective mucosal immunity against SARS-CoV-2 by an adenovirus-vectored nanoparticle vaccine

Abstract Effective vaccine design ideally elicits potent, durable, and broad-spectrum immunity against rapidly evolving pathogens. However, current platforms, such as recombinant adenovirus vectors and protein nanoparticles, are developed and administered separately, and each has distinct immunologi...

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Principais autores:	Shixiong Li, Qiong Zi, Junhao Fan, Guangzhen Jiang, Yao Zhang, Danni Feng, Zumrat Nur, Xiaoqing Liu, Jintao Lai, Tao Chen, Xiancai Ma, ZhangYong Hong, Jingyou Yu
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-03-01
Series:	Journal of Nanobiotechnology
Assuntos:	Adenoviral vectors Nanoparticle Antibody response T cell response GC reaction Self-assembly.
Acceso en liña:	https://doi.org/10.1186/s12951-026-04326-0
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