Variant selection to maximize variance explained in cis-Mendelian randomization

Summary: Optimal selection of instrumental variables (IVs) from a single gene region in cis-Mendelian randomization (MR) is challenging, as variants are highly correlated due to linkage disequilibrium (LD). Using only the lead variant is convenient but may not achieve full statistical power if multi...

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Autori principali:	Ang Zhou, Ville Karhunen, Haodong Tian, Janne Pott, Ashish Patel, Eric A.W. Slob, Stephen Burgess
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-04-01
Serie:	HGG Advances
Soggetti:	cis-Mendelian randomization cis-MR variant selection variance explained drug target Mendelian randomization linkage disequilibrium
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2666247726000138
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